Sophie von Hellermann lives and works in Margate and London. Recent solo and two-person exhibitions include Turner Contemporary, Margate, United Kingdom (2021); Greene Naftali, New York (2022, 2019, 2013, 2011); Kunstverein Hannover (2017); Firstsite, Colchester, United Kingdom (2013); and Le Consortium, Dijon, France (2010). Recent group exhibitions include Hayward Gallery, London (2021); Greene Naftali, New York (2021); X Museum, Beijing (2020); Bonner Kunstverein, Bonn (2016); Gallery Met, Metropolitan Opera, New York (2014); Cranford Collection, Fundación Banco Santander, Madrid (2013); and Tate Britain, London (2011).

Her work is in the collections of the Los Angeles County Museum of Art and The Metropolitan Museum of Art, New York, among others. Von Hellermann is a founding member of the London and Düsseldorf-based artists collective hobbypopMUSEUM, active since 2006.